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National Toxicology Program Selected Research

Papilloma (Papillomatosis)

2/2013Toxicology and carcinogenesis studies of pyrogallol (CAS No. 87-66-1) in F344/N rats and B6C3F1/N mice (dermal studies).
6/2010Toxicology and carcinogenesis studies of dibromoacetonitrile (CAS No. 3252-43-5) in F344/N rats and B6C3F1 mice (drinking water studies).
7/2008Toxicology and carcinogenesis studies of cresols (CAS No. 1319-77-3) in male F344/N rats and female B6C3F1 mice (feed studies).
4/2008Toxicology studies of allyl bromide (CAS No. 106-95-6) in genetically modified (FVB Tg.AC hemizygous) mice and carcinogenicity studies of allyl bromide in genetically modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] mice (dermal and gavage studies).
11/2007Toxicology and carcinogenesis study of glycidol (CAS No. 556-52-5) in genetically modified haploinsufficient p16(Ink4a)/p19(Arf) mice (gavage study).
9/2007NTP report on the toxicology studies of dicyclohexylcarbodiimide (CAS No. 538-75-0) in F344/N rats, B6C3F 1 mice, and genetically modified (FVB Tg.AC hemizygous) mice and carcinogenicity study of dicyclohexylcarbodiimide in genetically modified [B6.129-Trp53 tm1Brd (N5) haploinsufficient] mice (dermal studies).
9/2007Photocarcinogenesis study of glycolic acid and salicylic acid (CAS Nos. 79-14-1 and 69-72-7) in SKH-1 mice (simulated solar light and topical application study).
10/2005Toxicology studies of pentaerythritol triacrylate (technical grade) (CAS No. 3524-68-3) in F344/N rats, B6C3F1 mice, and genetically modified (FVB Tg.AC hemizygous) mice (dermal studies).
10/2005Toxicology studies of trimethylolpropane triacrylate (technical grade) (CAS No. 15625-89-5) in F344/N rats, B6C3F1 mice, and genetically modified (FVB Tg.AC hemizygous) mice (dermal studies).
5/2001Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies).
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National Toxicology Program Research Topics

Disease

89Carcinogenesis
12/2021 - 03/2000
72Body Weight (Weight, Body)
03/2019 - 03/2000
59Neoplasms (Cancer)
12/2021 - 03/2000
28Hyperplasia
02/2013 - 03/2000
17Carcinoma (Carcinomatosis)
12/2010 - 03/2000
15Adenoma (Adenomas)
12/2010 - 09/2000
13Chromosome Aberrations (Chromosome Abnormalities)
05/2011 - 03/2000
11Papilloma (Papillomatosis)
02/2013 - 03/2000
10Inflammation (Inflammations)
12/2012 - 03/2000
10Leukemia
09/2008 - 03/2000
8Hypertrophy
09/2012 - 07/2000
8Liver Cell Adenoma (Hepatocellular Adenoma)
12/2010 - 07/2000
7Liver Neoplasms (Liver Cancer)
12/2012 - 07/2000
7Necrosis
09/2008 - 03/2000
6Hepatoblastoma
12/2012 - 03/2000
6Atrophy
09/2012 - 09/2002
6Squamous Cell Neoplasms (Squamous Cell Cancer)
09/2010 - 07/2000
5Lymphoma (Lymphomas)
05/2012 - 03/2000
4Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2013 - 10/2003
4Malignant Mesothelioma
12/2012 - 07/2000
4Anemia
09/2012 - 03/2000
4Hemangiosarcoma (Angiosarcoma)
02/2009 - 03/2000
3Fibrosis (Cirrhosis)
09/2012 - 03/2000
3AIDS-Related Complex (ARC)
07/2012 - 09/2007
3Second Primary Neoplasms (Neoplasms, Second)
04/2008 - 03/2007
3Bronchiolo-Alveolar Adenocarcinoma (Adenocarcinoma, Bronchiolo Alveolar)
04/2007 - 07/2001
3Polycythemia (Erythrocytosis)
12/2002 - 09/2000
2Obesity
06/2020 - 07/2005
2Acquired Immunodeficiency Syndrome (AIDS)
10/2013 - 06/2006
2Polyps
12/2012 - 07/2010
2Methemoglobinemia
09/2012 - 09/2002
2Cyanosis
09/2012 - 05/2001
2Thinness
09/2012 - 11/2006
2Seizures (Absence Seizure)
11/2011 - 09/2000
2Hepatocellular Carcinoma (Hepatoma)
12/2010 - 09/2010
2Histiocytic Sarcoma
09/2010 - 11/2007
2Hemorrhage
08/2010 - 01/2003
2Prostatic Neoplasms (Prostate Cancer)
08/2010 - 07/2010
2Metaplasia
02/2009 - 09/2008
2Fibroadenoma
02/2009 - 07/2000
2Ulcer
05/2008 - 01/2001
2Birth Weight (Birth Weights)
03/2008 - 11/2004
2Skin Neoplasms (Skin Cancer)
09/2007 - 05/2002
2Dermatitis
10/2005 - 10/2005
2Kidney Neoplasms (Kidney Cancer)
09/2005 - 07/2000
2Poisoning
09/2003 - 05/2001
2Fibroma (Fibromatosis)
07/2001 - 07/2000
2Pheochromocytoma
07/2001 - 03/2000
1Neurodegenerative Diseases (Neurodegenerative Disease)
12/2021
1Pulmonary Fibrosis (Fibrosing Alveolitis)
07/2020

Drug/Important Bio-Agent (IBA)

17Drinking WaterIBA
11/2021 - 03/2000
17Corn Oil (Oil, Corn)IBA
03/2019 - 10/2003
11AcetoneIBA
11/2010 - 10/2005
8Ethanol (Ethyl Alcohol)IBA
02/2013 - 01/2001
5Diethylhexyl Phthalate (DEHP)IBA
12/2021 - 03/2003
5CarcinogensIBA
07/2020 - 01/2004
5Polychlorinated Biphenyls (PCBs)IBA
09/2006 - 01/2006
5Polychlorinated Dibenzodioxins (TCDD)IBA
09/2006 - 01/2006
5Polychlorinated DibenzofuransIBA
09/2006 - 01/2006
5DioxinsIBA
09/2006 - 01/2006
5Complex MixturesIBA
09/2006 - 01/2006
4phthalic acid (phthalate)IBA
12/2021 - 03/2003
43,4,5,3',4'-pentachlorobiphenylIBA
11/2006 - 01/2006
3Zidovudine (Retrovir)FDA LinkGeneric
10/2013 - 06/2006
3Biological ProductsIBA
07/2012 - 02/2006
3XenonIBA
07/2012 - 09/2007
3HemosiderinIBA
07/2012 - 03/2000
3Methylcellulose (BFL)IBA
11/2011 - 07/2000
3Cyclin-Dependent Kinase Inhibitor p16IBA
12/2007 - 10/2007
2EnzymesIBA
12/2019 - 02/2006
2Antiviral Agents (Antivirals)IBA
10/2013 - 05/2011
2Nevirapine (Viramune)FDA Link
10/2013 - 01/2013
2Hemoglobins (Hemoglobin)IBA
10/2013 - 09/2012
2Lamivudine (Epivir)FDA Link
10/2013 - 01/2013
2cumene (cumol)IBA
01/2013 - 02/2009
21-bromopropane (propyl bromide)IBA
01/2013 - 08/2011
2trimethylolpropane triacrylate (TMPTA)IBA
12/2012 - 10/2005
2LaxativesIBA
04/2012 - 06/2001
2Bile Acids and Salts (Bile Acids)IBA
03/2012 - 07/2000
22,3',4,4',5-pentachlorobiphenylIBA
11/2010 - 11/2006
2Oral ContraceptivesIBA
08/2010 - 07/2010
2Estradiol Congeners (Synthetic Estrogens)IBA
08/2010 - 07/2010
2Ethinyl Estradiol (Estinyl)FDA LinkGeneric
08/2010 - 07/2010
2GenisteinIBA
03/2008 - 01/2008
2Benzene (Benzole)IBA
10/2007 - 09/2002
2bromodichloromethaneIBA
05/2007 - 02/2006
2AcidsIBA
04/2007 - 01/2001
22,3,4,7,8-pentachlorodibenzofuranIBA
09/2006 - 09/2006
22,4,5,2',4',5'-hexachlorobiphenylIBA
08/2006 - 05/2006
2AnthraquinonesIBA
09/2005 - 06/2001
2Proteins (Proteins, Gene)FDA Link
07/2000 - 03/2000
1AntioxidantsIBA
12/2021
1Dibutyl Phthalate (Butyl Phthalate)IBA
11/2021
1sodium tungstate(VI) (sodium tungstate)IBA
11/2021
1Silicon Dioxide (Silica)FDA LinkGeneric
07/2020
1SandIBA
07/2020

Therapy/Procedure

4Therapeutics
03/2019 - 09/2000
2Drug Therapy (Chemotherapy)
03/2019 - 05/2013
2Traditional Medicine (Folk Remedies)
05/2011 - 08/2010
2Intraperitoneal Injections
05/2003 - 03/2000